Drogba, regarded as his nation’s greatest ever player, came on as a substitute in his side’s previous two matches.
Defender Kolo Toure and forward Salomon Kalou also start, having begun last week’s 2-1 loss to Colombia on the bench.
Greece also made three changes to the side that held Japan to a goalless draw in their last match.
Veteran midfielder Giorgos Karagounis replaces the suspended Kostas Katsouranis, taking the captain’s armband and winning his 138th cap.
Dmitris Salpingidis replaces the injured Kostas Mitroglou up front while Lazaros Christodoulopoulos comes into the midfield.
Greece: Karnezis; Torosidis, Papasthathopoulos, Manolas, Holebas; Karagounis, Maniatis, Christodoulopoulos, Kone, Salpingidis, Samaras
Ivory Coast: Barry; Aurier, K.Toure, Bamba, Boka; Tiote, Serey Die, Y.Toure, Kalou; Gervinho, Drogba