Spanish side Valencia defeated AA Gent 2-1 at the Mestalla Stadium.
Lasse Nielsen’s own goal had given the home side the lead before Thomas Foket equalised for the visitors.
But Stefan Mitrovic’s goal ensured Valencia left with all three points.
Zenit St Petersburg defeated French side Lyon 3-1 on home soil with goals coming from Artem Dzyuba, Danny and a brilliant long-range strike by Hulk.
Alexandre Lacazette scored for the Ligue 1 outfit.